GenR Next

Description

General Design

Type

Cohort study

Cohort type

Population cohort, Birth cohort

Data collection type

Retrospective, Prospective

Design

Longitudinal

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Design description

The Generation R Next Study is a population-based cohort study from preconception onwards. In total, about 3600 women are being included in the period 2017-2021. Of all included couples, about 30% is included during the preconception, about 60% during the first trimester of pregnancy and about 10% in the third trimester of pregnancy. Preconception recruitment is performed via social media, door-to-door mailings, mouth-to-mouth, and healthcare professionals. Measurements in the parents-to-be include physical examinations, questionnaires (lifestyle, diet) and biological samples at preconception, and 6 to 13 weeks pregnancy, as well as 30 weeks of pregnancy. The data collection includes innovative embryonic/fetal and placental assessments by repeated ultrasounds at around 6, 9, 12 and 30 weeks. Early childhood follow-up consisted of questionnaires at 1 month, 6 months and 12 months of age. A subgroup of children and their mothers was invited for measurements at the research center at ages 1 month, 6 months and 12 months.

Start/End data collection

2017 (ongoing)

Population

Continents

Europe

Countries

Netherlands (the)

Regions

Rotterdam

Number of participants

3604

Population age groups

Prenatal, Infant (0-23 months), Child (2-12 years)

Organisations

• Erasmus MC

  Netherlands (the)

  https://www.erasmusmc.nl

Contributors

• Vincent JaddoeErasmus MCv.jaddoe@erasmusmc.nl

  Principal Investigator

• Marieke WeltenErasmus MCm.welten@erasmusmc.nl

  Data manager

Data dictionaries

Networks

• 

  Advancing Tools for Human Early Lifecourse Exposome Research and Translation

  Children are particularly vulnerable to environmental hazards. The ATHLETE project will measure a wide range of environmental exposures (urban, chemical, lifestyle and social risk factors) during pregnancy, childhood, and adolescence. The project will then link this “early-life exposome” to children’s biological responses and cardiometabolic, respiratory, and mental health. The results will help us to better understand and prevent health damage from environmental agents from the earliest parts of the life course onward.

  WebsiteNetwork detailsCatalogue
• 

  Federated FAIR platform for cohort data connecting Europe and Canada

  EUCAN-Connect aims to promote collaborative and multidisciplinary research in high-value cohort and molecular data on a large scale in order to improve statistical power with the aims of making new discoveries about the factors that impact human life course and facilitating their translation into personalized diagnostics, treatment and prevention policies. The overall concept of EUCAN-Connect is: (1) Deploy FAIR federated data platform with a catalogue to make cohort data findable, accessible, interoperable and reusable and enable large-scale pooled analyses using federated DataSHIELD technologies and to deposit, curate and analyse data with privacy-protecting features that account for ethical, legal and societal implications; (2) Promote use of EUCAN-Connect platform, first proof-of-concept in smaller scientific communities focussed on cardio-metabolic, respiratory and musculoskeletal health and disease outcomes across the life course then scaling up to the wider cohort research community to maximize the diversity of data available; (3) Sustainably increase discovery power for personalized medicine using cohort data while involving public research infrastructures led by BBMRI-ERIC and involving, where possible, SMEs for professional support (including business models around data and infrastructure usage), starting with the one SME partner involved in this project. Using cutting edge information- and bio-technology, and building on extensive experience and understanding of the governance and handling of health-related research data, EUCAN-Connect will set up a meta-network that bridges existing and emerging cohort networks, federates currently parallel cataloguing and curation efforts, and standardizes, scales-up and matures cohort data access and federated analysis infrastructure.

  WebsiteNetwork detailsCatalogue
• 

  The EU Child Cohort Network

  The EU Child Cohort Network: A Europe-wide network of cohort studies started in early life Cohort studies started from pregnancy or childhood give the unique opportunity to relate early-life stressors with variation in development, health and disease throughout the life course. Moreover, advanced analytical approaches used in observational studies can help identify causality and potential for early-life interventions on factors that cannot be easily studied in experimental settings. These factors include socioeconomic circumstances, migration, urban environment as well as lifestyle-related determinants and will be given particular focus in our project. We will set up a European pregnancy and childhood cohort, the EU Child Cohort Network, which brings together extensive existing data from more than 250,000 European children and their parents. These cohorts enable studies in multiple generations because of their detailed phenotyping of both parents and children. The network will bring together existing successful multidisciplinary cohort studies, which all started before or during pregnancy or in childhood. Together, they span the full life course and contain detailed phenotypical information as well as biological samples. The EU Child Cohort Network will optimize exploitation of more than 40 available cohort resources in Europe and will enable innovative research on identification of novel markers of early-life stressors related to health trajectories throughout the full life cycle. Although LifeCycle partners and their cohorts have taken the initiative for this unique collaboration, the network is open to other partners with population-based cohorts started in early life, specifically those from Eastern and Southern Europe. To ensure that this will be a Europe-wide, open and sustainable network, which exceeds the LifeCycle Project duration, we will introduce a data sharing platform taking account of ethical, legal and societal implications, we will organize yearly meetings open to all European pregnancy and child cohort researchers and we will start a fellowship programme for exchange between these European cohorts.

  WebsiteNetwork detailsCatalogue
• 

  The LifeCycle Project

  A Europe-wide network of cohort studies started in early life Cohort studies started from pregnancy or childhood give the unique opportunity to relate early-life stressors with variation in development, health and disease throughout the life course. Moreover, advanced analytical approaches used in observational studies can help identify causality and potential for early-life interventions on factors that cannot be easily studied in experimental settings. These factors include socioeconomic circumstances, migration, urban environment as well as lifestyle-related determinants and will be given particular focus in our project. We will set up a European pregnancy and childhood cohort, the EU Child Cohort Network, which brings together extensive existing data from more than 250,000 European children and their parents. These cohorts enable studies in multiple generations because of their detailed phenotyping of both parents and children. The network will bring together existing successful multidisciplinary cohort studies, which all started before or during pregnancy or in childhood. Together, they span the full life course and contain detailed phenotypical information as well as biological samples. The EU Child Cohort Network will optimize exploitation of more than 40 available cohort resources in Europe and will enable innovative research on identification of novel markers of early-life stressors related to health trajectories throughout the full life cycle. Although LifeCycle partners and their cohorts have taken the initiative for this unique collaboration, the network is open to other partners with population-based cohorts started in early life, specifically those from Eastern and Southern Europe. To ensure that this will be a Europe-wide, open and sustainable network, which exceeds the LifeCycle Project duration, we will introduce a data sharing platform taking account of ethical, legal and societal implications, we will organize yearly meetings open to all European pregnancy and child cohort researchers and we will start a fellowship programme for exchange between these European cohorts.

  WebsiteNetwork detailsCatalogue
• 

  LongITools Health & Environment Dynamics

  LongITools is a European research project studying the interactions between the environment, lifestyle and health in determining the risks of chronic cardiovascular and metabolic diseases.

  WebsiteNetwork detailsCatalogue
• 

  Stay Healthy Through Ageing

  An Integrated Life-Course Approach for Person-Centred Solutions and Care for Ageing with Multi-morbidity in the European Regions – STAGE; Stay Healthy Through Ageing

  WebsiteNetwork detailsCatalogue
• 

  Global Exposome Cohorts

  The Global Exposome Cohort Catalogue is an international registry, based on the FAIR principle, of exposome cohorts with worldwide coverage. The objective is to generate a shared, public space for findability/discovery of cohorts with datasets that are relevant for the exposome field (i.e., that can contribute to answering exposome-related research questions), containing source metadata for each listed resource. We define a cohort as: a longitudinal population (birth, mother-child, adolescent, adult, or multi-generational) in which individual-level data are collected on health outcomes and/or exposures of interest. The Global Exposome Cohort Catalogue hosts metadata for each cohort, focusing on elements such as (Type of Cohort, Timing and duration of data collection, Exposure domains covered [e.g., chemical, urban, lifestyle, social], Geographical scope, Contact information for dataset access, Link to external website or data repository).

  Network detailsCatalogue

Access conditions

Data use conditions

not for profit, non commercial use only

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Release type

Periodically

Release description

Upon completion of follow-up, data will be cleaned for usage by the Generation R study group and then harmonized and uploaded for ECCN availability.